Carla Gugino was conceived in Sarasota, Florida, to Carl Gugino, an orthodontist. She is of Italian (father) and English-Irish (mother) ancestry. Gugino moved with her mom to Paradise, California, when Carla was only five years old.
During her childhood, they moved many occasions inside the state. In any case, she remained a straight-A student all through secondary school and graduated as valedictorian. A major modeling agency discovered Carla in San Diego and sent her to New York to start another career when she was 15. New York was beyond what she could handle at that youthful age, so she returned to LA in the late spring, modeling and taking a crack at an acting class at the recommendation of her aunt, Carol Merrill, known from Let’s Make a Deal (1963). During her leisure time, Carla appreciates yoga, traveling and spending time with her friends in Los Angeles.