Carla Gugino was conceived in Sarasota, Florida, to Carl Gugino, an orthodontist. She is of Italian (father) and English-Irish (mother) ancestry. Gugino moved with her mom to Paradise, California, when Carla was just five years old.
During her youth, they moved many times inside the state. In any case, she remained a straight-A student all through secondary school and graduated as valedictorian. A major demonstrating agency discovered Carla in San Diego and sent her to New York to start another career when she was 15. New York was beyond what she could handle at that youthful age, so she came back to LA in the summer, displaying and taking a crack at an acting class at the suggestion of her aunt, Carol Merrill, known from Let’s Make a Deal (1963). During her spare time, Carla enjoys yoga, traveling and spending time with her friends in Los Angeles.